预测ApoB/ApoA-I在第一次中风发生后1年内复发的预测值
Jie Lin1, Zhihua Si2, Aihua Wang2
1Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong Institute of Neuroimmunology, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong, China.
Frontiers in neurology
|January 26, 2024
概括
ApoB/ApoA-I比率是一个关键的胆固醇平衡指标,可以预测缺血性中风的复发. 在急性中风患者中,较高的比率与一年内中风复发风险增加有显著的相关性.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 生物化学 生物化学
背景情况:
- 无脂蛋白B (ApoB) /无脂蛋白AI (ApoA-I) 的比率是评估胆固醇平衡的公认标志物.
- 这一比率在预测缺血事件的风险方面尤为有价值.
研究的目的:
- 评估ApoB/ApoA-I比率的预后能力.
- 为了确定它与中风复发的关联,在最初的缺血性中风事件发生后的一年内.
主要方法:
- 对722名被诊断患有急性缺血性中风的患者进行了回顾性分析.
- 在入院时测量血清ApoB和ApoA-I水平.
- 统计分析,包括卡普兰-梅尔曲线和考克斯回归,以评估ApoB/ApoA-I比率与1年中风复发率之间的关系.
主要成果:
- 在一年内观察到14.1%的中风复发率.
- 经历复发的患者的入院ApoB/ApoA-I比率显著更高 (P < 0.001).
- 在对传统风险因素进行调整后,ApoB/ApoA-I比率与1年中风复发风险 (HR 4.007) 有显著的正相关性,即便如此.
结论:
- 在第一次中风的急性阶段测量的ApoB/ApoA-I比率是一年内再次中风的重要预测因素.
- 这种关联在不同患者亚组中保持强,包括那些具有不同LDL-C水平和特定类型的中风患者,如大动脉动脉样硬化 (LAA).
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