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一般医生的流行率. 在马来西亚的献血者中,Mur变异类型的现象

Siti Nazihahasma Hassan¹, Suharni Mohamad¹, Thirumulu Ponnuraj Kannan^1,2

¹School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Asian journal of transfusion science

|January 26, 2024

概括

葡萄糖蛋白 Mur (GP. Mur) 是马来西亚献血者中最常见的MNS血型系统变体,在6.94%的个人中发现. 这一发现对于预防免疫反应的输血政策至关重要.

科学领域:

血液学血液学血液学
免疫遗传学免疫遗传学
人口遗传学人口遗传学

背景情况:

MNS 血型系统包括具有多个免疫原抗原的甘氨酸变体,如 Mi ^a, Mur 和 MUT.
葡萄糖蛋白 (GP) 是一种蛋白质. 穆尔是东亚和东南亚人群中最常见的变体,表达了这三个抗原.

研究的目的:

为了确定MNS系统甘氨酸变体表型 (GP. 死亡记录,一般医生. 霍普,一般医生. 包,一般医生. 在HF,和GP. 在马来西亚的献血者身上.

主要方法:

一项涉及144名通过分层随机抽样选择的献血者的横截面研究.
从全血中提取DNA,然后进行聚合酶链反应 (PCR) 试验和桑格测序.
血清交叉匹配与抗Mur和抗MUT抗体进行验证.

主要成果:

家庭医生. 总医生. 在马来西亚6.94%的献血者中发现了Mur型表型.
没有其他MNS系统甘氨酸变体 (GP. 霍普,一般医生. 包,一般医生. 在HF,GP. 在这个队列中检测到的病例包括:

结论:

家庭医生. 家庭医生. 穆尔被证实是马来西亚献血者中占主导地位的甘氨酸 (B-A-B) 混合变体.
在GP的存在. 穆尔需要考虑全科医生. 在输血策略中,Mur阴性红细胞.
这种方法旨在减轻与免疫接种和免疫介导的输血反应,特别是在依赖输血的患者中.

关键词:

家庭医生. 家庭医生. 在这里,我们可以看到MUR MUR MUR.在MNS血型系统中,MNS是血型系统.在MNS中,混合型甘氨酸是MNS混合型甘氨酸.这种MNS变体的表型是MNS变体.马来西亚人是马来西亚人.

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