人类白细胞抗原与血液输血中的免疫预防机制
Tiruneh Adane1, Bamlaku Enawgaw1
1Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Asian journal of transfusion science
|January 26, 2024
概括
在输血期间预防人类白细胞抗原 (HLA) 免疫接种至关重要. 通过过去除白细胞 (WBCs) 是最有效的方法来减少初级HLA配免疫,并改善患者的治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
- 血液学 血液学 血液学
背景情况:
- 人类白细胞抗原 (HLA) 系统在临床医学和输血中至关重要.
- 输血期间对外来抗原的免疫反应,导致针对红细胞 (RBC),HLA或人类血小板抗原 (HPA) 的艾洛抗体.
- 输血后的HLA合免疫通常是血液产品中白细胞 (WBC) 受到污染的结果,导致输血不耐受性和折射性.
研究的目的:
- 调查白细胞在HLA与免疫接种中的作用.
- 评估预防HLA与免疫接种的方法.
- 确定减少初级HLA与免疫接种的最有效策略.
主要方法:
- 对有关HLA合免疫和输血并发症的现有文献的审查.
- 分析防止HLA合免疫的机制,包括白血病减少,HLA匹配和辐射.
- 通过过去除白血细胞作为预防措施的评估.
主要成果:
- 血液制品中污染的白血球是HLA合免疫的主要原因.
- 诸如白血病减缓和HLA匹配等各种方法可以帮助预防异免疫.
- 通过过去除白细胞被确定为最大限度地减少初级HLA合免疫化的最佳方法.
结论:
- 有效预防HLA合免疫是成功输血治疗的关键.
- 过以去除白血球代表了减少初级HLA配免疫发生率的最佳策略.
- 通过过来进行白血球去除可以显著改善患者对输血的耐受性和反应.
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