快速眼动睡眠行为障碍与帕金森病中的执行功能之间的相关性和潜在的大脑机制:一项fNIRS研究
Lu Ren1, Xiaoxue Yin1, Hai-Yang Wang1
1Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in aging neuroscience
|January 26, 2024
概括
在帕金森病 (PD) 患者中,快速眼动睡眠行为障碍 (RBD) 与前额叶大脑活化减少和执行功能障碍有关. 这种功能障碍可能会随着RBD严重程度的增加而恶化,影响认知健康.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 快速眼动睡眠行为障碍 (RBD) 影响30-40%的帕金森病患者.
- 脊髓损伤与认知障碍,特别是执行功能障碍的风险增加有关.
研究的目的:
- 为了研究患有或没有RBD的PD患者的大脑激活模式.
- 分析大脑皮层活动与PD中RBD严重程度之间的相关性.
主要方法:
- 在口语流利任务 (VFT-fNIRS) 中利用功能近红外光谱 (fNIRS).
- 包括50名PD患者 (30名PD-RBD+,20名PD-RBD-) 和20名健康对照 (HC).
- 进行了临床神经心理评估.
主要成果:
- 与没有RBD (PD-RBD-) 和HCs的PD患者相比,患有RBD (PD-RBD+) 的PD患者的前额叶皮层激活显著减少.
- 在背侧前额皮层 (DLPFC) 和腹侧前额皮层 (VLPFC) 观察到活性减少.
- 在右侧DLPFC激活和RBD严重程度之间发现了负相关性.
结论:
- 在PD患者中,RBD会加剧认知障碍和执行功能障碍.
- 降低前额活化是这种恶化的关键神经相关因子.
- 大脑激活的变化可能与PD中的RBD严重程度有关.
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