导致失明的糖尿病视网膜病变 - - 综述
Amandeep Kaur1, Ranjeet Kumar1, Amit Sharma1
1Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab, India.
Current diabetes reviews
|January 26, 2024
概括
糖尿病视网膜病变 (DR) 是导致失明的主要原因. 改变生活方式和补充剂可能会预防DR,而先进的治疗方法,如抗VEGF注射和传统中医药,显示出对控制其进展的希望.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病的严重微血管并发症,可能导致失明.
- 与2型糖尿病相比,1型糖尿病对DR发展的风险更高.
- 抑郁症被分为增殖性 (PDR) 和非增殖性 (NPDR) 形式,受高血压,肥胖,吸烟,糖尿病持续时间和遗传等因素的影响.
研究的目的:
- 审查糖尿病视网膜病变的风险因素,潜在机制和治疗策略.
- 探索炎症化学因子,血管生成因子 (如VEGF,PDGF) 和抗血管生成因子 (如PEDF) 在DR中的作用.
- 评估糖尿病视网膜病变的预防措施和新兴治疗方法.
主要方法:
- 对研究DR病理生理学和治疗的文献综述.
- 对风险因素的研究分析,包括生活方式和遗传倾向.
- 评估DR患者眼液和血清中的生化标志物.
主要成果:
- 在DR玻璃体液中观察到高水平的血管生成因子 (VEGF,PDGF) 和降低的抗血管生成因子 (PEDF).
- 增加体力活动和减少久坐行为与较低的DR风险有关.
- 含有特定维生素和的营养药可能有助于预防DR爆发.
结论:
- 生活方式的修改和营养补充提供了糖尿病视网膜病变的预防策略.
- 目前严重DR的有效治疗方法包括激光光凝和抗VEGF注射.
- 传统中国医学 (TCM) 提出了一个有前途的未来治疗途径,用于管理DR中的VEGF水平,炎症,氧化应激,亡和血管生成.
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