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Updated: Jul 4, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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在小细胞肺癌中基蛋白导向剂和MYC

Gerhard Hamilton1, Sandra Stickler1, Barbara Rath1

  • 1Institute of Pharmacology, Medical University of Vienna, Vienna, Austria.

Current cancer drug targets
|January 26, 2024
PubMed
概括

针对BRD4的新型PROTAC显示出治疗小细胞肺癌 (SCLC) 的前景. ARV-825显示出显著的抗癌作用,可能改善这种侵袭性神经内分泌癌症的化疗结果.

关键词:
BET 抑制剂是 BET 抑制剂.的DNA损伤反应 (DDR).在MYC的Paralogs中.这就是PROTAC.小细胞肺癌是一种小细胞肺癌.原蛋白质的蛋白质.

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