在患有帕金森病的老年患者中评估缩症和相角
Merve Yilmaz1, Yasemin Atik-Altinok2, Dilek Seyidoglu Yüksel2
1Faculty of Health Science, Department of Nutrition and Dietetics, İzmir Tinaztepe University, İzmir, Turkey.
The International journal of neuroscience
|January 26, 2024
概括
这项研究确定了<4.5°的相角 (PhA) 切线,以检测帕金森病 (PD) 患者的肉症. 早期发现肉类和相关因素对于管理PD进展至关重要.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 营养科学 营养科学
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,影响着运动能力和生活质量.
- 随着年龄的增长而导致的肌肉损失 - - 萨科佩尼亚 - - 在老年人群中很常见,PD可能会使其恶化.
- 在PD患者中早期发现肉类症对于及时干预至关重要.
研究的目的:
- 调查老年帕金森病患者的萨尔科佩尼亚和相关因素.
- 为了确定一种特定于疾病的相角 (PhA) 切线分数,用于在PD中检测肉症.
- 探索PhA,营养状况,身体活动和疾病严重程度之间的关系.
主要方法:
- 一项涉及89名PD患者的横截面研究.
- 使用了迷你营养评估 (MNA),饮食态度测试-10 (EAT-10) 和老年人身体活动量表 (PASE).
- 使用EWGSOP2标准诊断的肉;通过生物电阻分析 (BIA) 测量PhA.
主要成果:
- 在研究队列中,肉类的患病率为12.3%.
- 与皮症相关的因素包括PhA,营养不良,年龄,疾病严重程度,低腿周长 (CC),低体重指数 (BMI),体重减轻,多巴胺治疗和低PASE分数.
- 一个PhA切线<4.5°显示了53.3%的灵敏度和93.2%的特异性来检测肉症 (p=0.001).
结论:
- 对于帕金森病患者的早期干预来说,意识到肉类及其相关因素至关重要.
- 一个疾病特定的PhA切断值得分可能更适合在PD中定义因疾病相关症状而导致的肉症.
- PhA,疾病严重程度和体力活动水平与PD中的肉症有显著的相关性.
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