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休息心率,但不是心率变化与正常体重肥胖现型相关
Abel Plaza-Florido1,2, Jonatan R Ruiz2,3,4, Juan M A Alcantara2,3,5,6
1Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, Irvine, USA.
概括
正常体重肥胖 (NWO) 的年轻人比正常体重瘦 (NWL) 个体的休息心率 (HR) 高,尽管心率变化率 (HRV) 类似. 这一发现表明HR可能表明看似健康的正常体重个体的潜在心血管风险.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 运动生理学 运动生理学
背景情况:
- 正常体重肥胖 (NWO) 越来越被认为是一种独特的表型,具有潜在的健康影响.
- 患有NWO的人可能表现出新陈代谢和心血管异常,尽管他们的体重指数 (BMI) 正常.
- 了解NWO中的心血管生物标志物对于早期风险检测至关重要.
研究的目的:
- 为了比较NWO和正常体重瘦 (NWL) 个体的年轻成年人之间的静止心率变化 (HRV) 和心率 (HR).
- 调查HRV和HR.反映在自主神经系统功能中的潜在差异.
- 确定简单的生理测量是否可以区分NWO和NWL表型.
主要方法:
- 横截面研究包括65名正常体重 (18-25岁) 个体.
- 通过双能X射线吸收计 (DXA) 评估的身体脂肪百分比.
- 使用极地RS800CX测量的休息HRV和HR; NWO定义为身体脂肪百分比截止值.
主要成果:
- 在NWO和NWL组之间没有观察到休息心率变化 (HRV) 的显著差异 (p > .05).
- 与NWL组 (平均65bpm) 相比,NWO组 (平均70bpm) 的休息心率 (HR) 显著更高.
- 调整后HR的平均差异为5bpm (95%CI,0到10bpm).
结论:
- 休息心率 (HR) 可能作为一个简单的,非侵入性的生物标志物来识别年轻,看似健康的,体重正常的个体,具有不良的心血管疾病风险概况.
- HRV似乎没有区分正常体重的肥胖和正常体重的瘦年轻人.
- 在NWO个体中HR升高需要进一步调查他们的心血管健康状况.
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