研究人员暴露在工程纳米颗粒中的高谷氨,这是由于潜在的适应氧化应激
Pavlina Klusackova1, Lucie Lischkova1, Viktoriia Kolesnikova1
1Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague & General University Hospital in Prague, Prague, 128 00, Czech Republic.
Nanomedicine (London, England)
|January 26, 2024
概括
暴露于纳米颗粒的研究人员在血和呼出的呼吸凝聚物 (EBC) 中显示了较高的谷氨 (GSH) 水平,表明了适应性反应. 这表明GSH是对纳米粒子暴露和氧化应激的实际生物监测器.
科学领域:
- 职业健康 职业健康 职业健康
- 环境科学 环境科学
- 生物化学 生化学
背景情况:
- 纳米粒子暴露带来风险,包括氧化应激.
- 需要生物监测方法来评估研究人员的暴露.
- 之前的研究 (2016-2018) 为当前的研究奠定了基础.
研究的目的:
- 建立一个实用的生物监测方法,用于纳米粒子暴露.
- 调查研究人员的氧化应激和抗氧化剂状况.
- 为了将纳米粒子暴露水平与生物标记者相关联.
主要方法:
- 从研究人员和对照组收集的生物样本 (血,尿液,EBC)
- 通过光谱测量评估抗氧化状态 (谷氨,降低铁的抗氧化能力) 和氧化应激 (thiobarbituric酸反应物质).
- 监控研究人员的个人纳米粒子暴露.
主要成果:
- 研究人员在暴露前和暴露后观察到血谷氨 (GSH) 的升高 (p < 0.01).
- 暴露后的血GSH与纳米粒子暴露水平相关.
- 在呼出的呼吸凝凝液 (EBC) 中检测到增加的GSH水平.
结论:
- 血和EBC谷氨 (GSH) 作为有效的生物监测对纳米粒子暴露.
- 研究结果表明,对长期纳米粒子暴露有适应性反应.
- 该研究提供了一种评估职业纳米粒子暴露的实用方法.
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