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Camila Aparecida de Carvalho¹, Roberto Mitsuyoshi Hiramoto², Luciana Regina Meireles¹

¹Laboratório de Protozoologia IMTSP, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.

Parasite immunology

|January 26, 2024

概括

在内脏莱什曼病 (VL) 中,非特异性高血糖球蛋白血症 (HGG) 与疾病进展相关. 在子和狗中观察到的这一发现表明,HGG可能作为活跃VL感染的标志物.

科学领域:

免疫学免疫学免疫学
寄生虫学的寄生虫学
兽医医学兽医医学兽医医学

背景情况:

非特异性高血糖球蛋白血症 (HGG) 观察到症状的人体内皮质莱什曼病 (VL),由婴儿莱什曼病引起.
了解HGG在实验和自然VL感染中的作用对于诊断和预后见解至关重要.

研究的目的:

在实验性仓鼠和自然犬内脏莱什曼病 (VL) 模型中评估非特异性高甘球蛋白血症 (HGG).
研究VL中HGG,特定抗体和循环免疫复合体 (IC) 之间的关联.

主要方法:

血清蛋白质,白蛋白和血球蛋白度测量使用酸盐和布罗莫克雷索尔绿色反应.
专蛋白/血球蛋白 (A/G) 比率被用来表达HGG.
特定的抗甘氨酸抗体和循环免疫复合体 (IC) 使用酶相关免疫吸收试验 (ELISA) 检测到.

主要成果:

在感染的子和狗中,HGG与特定抗体 (抗BSA-G/PSE) 和循环免疫复合体 (IC) 的较高度有关.
从受感染的子和狗的血清中检测到很大比例的单价IC,随着疾病的进展而增加.
在狗中,HGG与增加的特异性免疫球蛋白 (Ig) A和IgM相关,但不是IgG,以及单价IC的存在.

结论:

VL中的HGG可能是由于非特异性B细胞激活和抗体产生增加,可能与因IC而减少的IgG分泌相结合.
HGG与内脏莱什曼病的进展相关.
HGG可以作为表现为VL疾病的潜在生物标志物.

关键词:

莱什曼尼亚 L. 婴儿这些狗狗狗狗狗狗狗.哈姆斯特丹哈姆斯特丹哈姆斯特丹是一个超高麦球蛋白血症的发生.免疫复合体的免疫复合体有关内脏的莱什曼病.

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