手术抗生素预防:关于全球基于证据的综合方案的建议
Massimo Sartelli1, Federico Coccolini2, Francesco M Labricciosa3
1Department of Surgery, Macerata Hospital, 62100 Macerata, Italy.
Antibiotics (Basel, Switzerland)
|January 26, 2024
概括
本综述介绍了一套手术抗生素预防 (SAP) 包,以预防手术部位感染 (SSI). 基于证据的包包括五项措施,用于正确管理SAP,促进全球医院的安全和协作.
科学领域:
- 预防和控制感染的预防和控制.
- 外科手术的安全性
- 抗微生物药物管理委员会
背景情况:
- 与医疗保健相关的感染,特别是手术部位感染 (SSIs),构成了重大的临床挑战.
- 手术抗生素预防 (SAP) 是预防SSI的一个关键措施.
- 现有的指导方针需要适应当地实施和常规临床护理.
研究的目的:
- 为正确的手术抗生素预防 (SAP) 管理提供一个全面的包.
- 评估支持拟议的SSI预防SAP包的证据.
- 促进将SAP中的最佳实践转移到常规临床护理中.
主要方法:
- 对国际指南 (世卫组织,疾病预防控制中心,NICE,SHEA/IDSA/APIC/AHA,ASHP/IDSA/SIS/SHEA) 的叙述性审查,用于SSI预防和SAP.
- 在PubMed®/MEDLINE和Google Scholar中进行全面的文献搜索,以支持证据.
- 确定和综合优化SAP管理的关键干预措施.
主要成果:
- 为SAP管理制定了一套五项措施,适用于全球.
- 关键建议包括适当的患者选择,时间 (切口前60分钟内),再剂量标准和术后停药.
- 该包基于药理动力学/药理动力学原则,并强调跨学科的方法.
结论:
- 拟议的SAP包提供了一个基于证据的,易于实施的预防SSI的战略.
- 它促进了抗微生物药物管理,并支持了机构安全文化的发展.
- 该包鼓励合作,可以在全球所有医疗保健机构有效监控.
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