与阻塞性睡眠呼吸暂停中大脑结构和功能的改变相关的基因
Yijie Huang1, Chong Shen2, Wei Zhao1,3,4
1Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Biomedicines
|January 26, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 改变大脑结构和功能,影响诸如海马和杏仁体等区域. 基因分析揭示了这些大脑变化与突触活动之间的联系.
科学领域:
- 神经成像是一种神经成像.
- 遗传学 遗传学 是一个
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与大脑结构和功能异常有关.
- 驱动OSA中这些神经变化的潜在遗传机制尚不清楚.
- 研究睡眠,认知,遗传学和大脑变化之间的相互作用至关重要.
研究的目的:
- 探索睡眠特征,认知障碍,遗传因素和OSA患者的大脑结构/功能之间的关系.
- 确定与OSA中神经成像发现相关的遗传机制.
主要方法:
- 结构性和休息状态功能性MRI (fMRI) 用于评估大脑结构和活动.
- 进行了基于voxel的形态学 (VBM) 和低频波动幅度 (ALFF) 分析.
- 转录组-神经成像空间相关性分析集成基因表达数据与神经成像发现.
主要成果:
- OSA患者在海马体,杏仁体,尾状体和小脑中显示ALFF增加,在前体中显示ALFF降低.
- 在OSA患者中,VBM分析表明右下壁叶灰质体积 (GMV) 增加.
- 功能性丰富分析将与ALFF和GMV变化相关的基因与封闭通道活动,突触传播和谷氨酸突触相关联.
结论:
- OSA与大脑活动和灰质体积的明显变化有关.
- 与突触功能和通道活动相关的遗传因素可能是这些OSA诱导的大脑变化的基础.
- 对这些遗传机制的进一步研究可以为与OSA相关的神经缺陷的有针对性的干预提供信息.
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