相关实验视频
Updated: Jul 4, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
在一个高度精选的肌病患者群体中进行炎症概况评估,这些患者接受了受控和标准化的甲状腺功能减退症
Tommaso Piticchio1,2, Francesco Savarino1, Salvatore Volpe1
1Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, 95124 Catania, Italy.
Biomedicines
|January 26, 2024
概括
这项研究检查了标准化甲状腺功能低下症患者的血液炎症指数. 研究结果表明,这些指数可能有助于评估肥胖个体的甲状腺功能低下症,并作为甲状腺癌的预后标志物.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺功能低下症 (hT) 的症状是多样化的,经常在不同的患者群体中进行研究.
- 评估系统性炎症需要一个均的甲状腺功能低下症人口.
- 这项研究侧重于受控甲状腺功能低下症队列中的炎症.
研究的目的:
- 通过血液炎症指数 (BIIXs) 在同质的甲状腺功能低下患者群体中研究系统性炎症.
- 在I131治疗前对经过标准化甲状腺功能低下症的甲状腺切除术患者分析BIIX.
- 探索BIIXs,患者人口统计和甲状腺激素水平之间的相关性.
主要方法:
- 招募了143名甲状腺切除术的甲状腺癌患者,他们患有甲状腺功能低下症.
- 从I131治疗前的血液测试中计算的BIIX (NLR,PLR,MLR,SII,SIRI,AISI) 结果.
- 分析了基于性别,BMI,甲状腺蛋白的BIIX差异,以及与年龄和甲状腺激素的相关性.
主要成果:
- 根据性别,BMI和甲状腺球蛋白水平 (p <0.05) BIIX中位数值有显著差异.
- 在BIIX和年龄,TSH,FT4或FT3.3之间没有观察到显著的相关性.
- 该研究为标准化甲状腺功能低下症队列提供了BIIX值的中位数.
结论:
- 这项研究为标准化甲状腺功能低下症人群建立了BIIX参考值.
- 某些BIIX可能有助于评估甲状腺功能低下症,特别是在肥胖患者中.
- BIIXs显示出作为甲状腺癌管理的预后标记物的潜力.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
92
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Inflammation
53.4K
Overview
53.4K

