尼亚对热应激性肉牛皮肤上皮细胞屏障完整性的保护作用
Bicheng Zou1, Fan Long1, Fuguang Xue1
1Jiangxi Province Key Laboratory of Animal Nutrition, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang 330045, China.
Animals : an open access journal from MDPI
|January 26, 2024
概括
热应激会损害肉牛的膜屏障,增加肠道的透性. 氨酸补充剂通过改善紧结蛋白表达和保持肠道完整性来防止这种情况.
科学领域:
- 动物科学动物科学
- 生理学 生理学 生理学
- 营养 营养 营养 营养 营养
背景情况:
- 热应激对肉牛的健康和生产力产生负面影响.
- 皮上皮屏障的完整性对于维持生理功能至关重要.
- 肠道透性是肠道健康的一个关键指标.
研究的目的:
- 为了研究氨酸补充剂对热应激性肉牛皮表皮屏障功能的影响.
- 为了阐明氨酸在减轻热应激引起的肠透性的作用.
- 分析氨酸对紧结蛋白表达和炎症反应的影响.
主要方法:
- 12只晋江公牛被分为热中性 (TN),热压力 (HS) 和热压力 niacin-supplemented (HN) 组.
- 测量了D-乳酸,DAO,LPS和细胞因子的血度.
- 评估了紧结蛋白 (ZO-1,克劳丁,奥克卢丁) 的基因表达.
主要成果:
- 热应激增加了D-乳酸,LPS和炎症性细胞因子水平,同时降低了IL-4.
- 氨酸补充剂降低了LPS和炎症标志物,并增加了IL-4.
- 热应激降低了紧结蛋白mRNA表达的调节; 氨酸上调了ZO-1和奥克卢丁.
结论:
- 热应激会损害膜屏障功能,并通过降低紧密结合蛋白的调节,增加肠道的透性.
- 补充尼亚可以减轻这些负面影响,保护热应激牛的膜屏障.
- 尼亚显示出作为一种饮食策略,在热应激下维持肉牛肠道完整性的潜力.
相关概念视频
01:25Mucosal Barrier of the Stomach
662
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
662
02:45Responses to Heat and Cold Stress
13.5K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.5K