绵羊和山羊中Orf病毒的全球进化历史由整个基因组数据揭示
Elisabetta Coradduzza1, Fabio Scarpa2, Angela Maria Rocchigiani1
1Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Viruses
|January 26, 2024
概括
奥尔夫病毒 (ORFV) 是绵羊和山羊传染性湿疹的原因,在物种之间显示出不同的遗传结构. 这项研究使用全球基因组数据揭示了它们在20世纪末出现的情况.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子进化分子进化
- 动物传播疾病 动物传播疾病
背景情况:
- 奥尔夫病毒 (ORFV) 是一种Parapoxvirus,导致传染性湿疹 (CE),这是全球小型反动物的重要经济疾病.
- 在密集繁殖的绵羊和山羊中发生了CE疫情,并在野生动物中观察到.
- ORFV是动物传染的,对人类健康构成风险.
研究的目的:
- 研究羊和山羊Orf病毒 (ORFV) 基因组的全球进化史.
- 将中美洲的新 ORFV 基因组纳入进化分析中.
- 改进ORFV凝聚事件的分子约会,并分析遗传结构.
主要方法:
- 从绵羊和山羊的Orf病毒 (ORFV) 整个基因组的综合数据集的家族遗传学分析.
- 包括11个新的绵羊和山羊ORFV基因组,数据集大小增加了42%.
- 分子约会技术用于估计ORFV血统的凝聚时间.
主要成果:
- 羊 (S) 和山羊 (G) 的ORFV基因组的凝聚时间的详细分子约会.
- 在羊衍生和山羊衍生ORFV基因组之间观察到显著的遗传结构.
- 证实了这些ORFV血统在20世纪下半叶的出现.
结论:
- 绵羊和山羊中Orf病毒 (ORFV) 的进化历史以不同的遗传血统为特征.
- 全球基因组数据,包括新的中美洲菌株,完善了我们对ORFV出现的理解.
- 这些发现支持20世纪末出现的与绵羊和山羊相关的ORFV菌株.
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