双边肺移植后的真菌感染和殖民:一个为期六年的单中心经验
Annalisa Boscolo1,2,3, Annamaria Cattelan4, Serena Marinello4
1Department of Medicine, University of Padua, 35122 Padua, Italy.
Journal of fungi (Basel, Switzerland)
|January 26, 2024
概括
一年内,8%的肺移植接受者 (LTRs) 发生真菌感染,23%的人经历了殖民,主要是Aspergillus. 在预防策略之间没有发现特定的风险因素或结果的差异.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 移植手术 移植手术
背景情况:
- 真菌感染 (FIs) 是肺移植接受者 (LTRs) 在移植后第一年内发病和死亡的重要原因.
- 早期发现和治疗FI对于改善LTR结果至关重要.
- 在这种患者群体中,Aspergillus物种是真菌殖民的常见原因.
研究的目的:
- 评估双边肺移植后第一年FI和真菌殖民的发病率.
- 识别与FI和殖民化相关的风险因素.
- 为了比较不同预防性抗真菌策略的真菌发病率.
主要方法:
- 在帕多瓦大学医院对双边LTR进行回顾性查.
- 排除标准包括年龄<18岁,再移植和前LT机械支.
- 对157个LTR进行分析,以确定FI和殖民率以及相关因素.
主要成果:
- 整体FI发病率为8% (13名患者),真菌殖民率为23% (36名患者).
- 亚斯伯菌 spp. 的种类. 是在殖民病例中发现的占主导地位的生物体.
- 没有确定FI的独立风险因素,并且在接受不同预防策略的组之间没有观察到FI或殖民率的显著差异.
结论:
- 该研究发现,在双边肺移植后的第一年,FI的发病率为8%,真菌殖民的发病率为23%.
- 没有发现与抗真菌预防策略相关的显著诱导因素或结果差异.
- 需要进行更大规模的研究来验证这些发现,并进一步调查风险因素和最佳预防措施.
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