疾病修饰疗法对肠-大脑轴在多发性硬化症中的影响
Ilaria Del Negro1,2, Sara Pez1,2, Salvatore Versace1,2
1Clinical Neurology Unit, Udine University Hospital, Piazzale S. Maria della Misericordia, 33100 Udine, Italy.
Medicina (Kaunas, Lithuania)
|January 26, 2024
概括
多发性硬化症 (MS) 的疾病修饰疗法 (DMT) 可能会影响肠道微生物群. 本综述探讨了这些治疗方法如何影响MS患者的肠-大脑轴,尽管直接影响仍然不清楚.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 环境因素,特别是肠道微生物组的改变,越来越多地与MS的发病有关.
- 肠道平衡和自身免疫调节之间的相互作用是关键的研究领域.
研究的目的:
- 审查疾病修饰疗法 (DMT) 对多发性硬化症患者肠道微生物群的影响.
- 在MS的背景下阐明DMTs对微生物群-肠-大脑轴的影响.
- 突出目前对DMT对肠道微生物群的直接影响的理解和不确定性.
主要方法:
- 对调查多发性硬化病原和环境因素的研究进行文献综述.
- 对成员国肠道微生物组组成和肠道屏障功能的研究分析.
- 检查疾病修饰疗法 (DMT) 对肠道微生物群和免疫反应的影响数据.
主要成果:
- 肠道微生物组和肠道透性的改变与MS自身免疫有关.
- 对于MS而言,疾病修饰疗法 (DMT) 具有免疫调节作用,可能会影响肠道微生物群.
- 目前MS治疗对肠道微生物群的直接影响尚未完全理解.
结论:
- 肠道微生物群在多发性硬化症复杂的发病过程中发挥着重要作用.
- 疾病修饰疗法 (DMT) 可能通过它们对肠道微生物群的影响来调节免疫反应.
- 需要进一步的研究来澄清DMT对MS微生物群-肠-大脑轴的直接影响.
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