卡路里限制和间歇性禁食对大脑衍生的神经营养因子水平和人类认知功能的影响:系统性审查
Refat Alkurd1, Lana Mahrous2, Falak Zeb3
1Department of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Medicina (Kaunas, Lithuania)
|January 26, 2024
概括
间歇性禁食 (IF) 对人类的脑源性神经营养因子 (BDNF) 和认知功能产生混合影响. 需要更多的研究来了解各种IF疗法对BDNF和认知的长期影响.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 间歇性禁食 (IF) 与来自大脑的神经营养因子 (BDNF) 之间的关系对认知功能具有重要意义.
- 本文审查了各种IF方法,包括热量限制 (CR),交替日禁食 (ADF),时间限制饮食 (TRE) 和斋月间歇性禁食 (RIF).
研究的目的:
- 系统地审查各种FI疗法在BDNF水平上的疗效.
- 评估IF诱导的BDNF变化与人类认知功能之间的关联.
主要方法:
- 实验和观察研究的系统审查.
- 在EMBASE,Scopus,PubMed和谷歌学者中进行了搜索 (2000年1月至2023年12月).
- 按照PRISMA指南进行研究选择和报告.
主要成果:
- 对健康个体和代谢障碍患者进行的16项研究符合纳入标准.
- 五项研究报告BDNF增加,5项报告BDNF减少,6项没有发现显著变化.
- 对BDNF的RIF干预显示出混合的结果,一些研究指出认知能力有所改善.
结论:
- 间歇性禁食 (IF) 在不同人群中对BDNF水平和认知功能产生了可变的影响.
- 目前的人类研究提供了关于IF提高BDNF的能力有争议的证据.
- 进一步进行大规模,高质量的研究是必不可少的,以澄清IF疗法对BDNF和认知健康的长期影响.
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