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萨尔科佩尼亚和骨质量减少之间的关联:骨质沙科佩尼亚肥胖症是应在体重管理环境中考虑的新现象吗?
Antonino De Lorenzo1, Leila Itani2, Paola Gualtieri1
1Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Life (Basel, Switzerland)
|January 26, 2024
概括
肥胖症 (SO) 与肥胖个体的骨矿物质含量较低有关. 一种新的疾病 - - 骨髓缩性肥胖症 (OSO),结合了多余的脂肪,低肌肉和低骨质量,影响了这个人口的16%.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 骨和矿物质的新陈代谢
背景情况:
- 肥胖症 (SO) 在肥胖的人群中很常见.
- SO与骨健康之间的关系尚未得到充分理解.
- 骨质状况下降可能会加剧肥胖人口的健康问题.
研究的目的:
- 为了研究 sarcopenic 肥胖 (SO) 和低骨质量之间的关联.
- 为了确定骨髓缩性肥胖 (OSO) 的患病率,一种结合SO和低骨质量的新型表型.
- 分析SO对肥胖成年人骨矿物质含量 (BMC) 的影响.
主要方法:
- 双能X射线吸收仪 (DXA) 扫描用于评估2604名肥胖参与者的身体组成和骨矿物质含量 (BMC).
- 参与者根据SO (多余脂肪,肌肉质量/力量减少) 和低或正常的BMC的存在来分类.
- 新的表型,骨类肥胖症 (OSO),被定义为存在SO和低BMC.
主要成果:
- 34.6%的参与者患有sarcopenic肥胖症 (SO).
- 与没有SO的人相比,SO患者的平均BMC显著降低 (2.56±0.46对2.85±0.57,p<0.01).
- SO与92%增加患有低BMC (OR = 1.92;95%CI: 1.60-2.31,p < 0.05) 的几率有关,即使调整了年龄,体重和身体脂肪百分比.
- 骨髓缩性肥胖 (OSO) 影响了总样本 (426名参与者) 的16.4%.
结论:
- 在肥胖的成年人中,sarcopenic肥胖症 (SO) 与骨质减少密切相关.
- 骨髓缩性肥胖 (OSO) 是一种新发现的表型,影响着肥胖人口的很大一部分 (16.4%).
- 这项研究强调了肥胖中脂肪,肌肉和骨健康之间的复杂相互作用,强调了综合评估和管理策略的必要性.
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