-肠轴作为营养干预的新目标,以抵制慢性病进展
Sandra Cabała1, Małgorzata Ożgo1, Agnieszka Herosimczyk1
1Department of Physiology, Cytobiology and Proteomics, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology Szczecin, Klemensa Janickiego 29, 71-270 Szczecin, Poland.
均衡的饮食会影响肠道微生物,影响脏健康和慢性病 (CKD) 的进展. 特定的营养素和化合物可能通过调节肠轴提供治疗效益.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 饮食显著影响肠道微生物群的组成和功能.
- 肠道功能失调和微生物代谢物 (尿素毒素) 导致慢性病 (CKD) 发病,炎症和氧化应激.
- 肠-轴突出了肠道健康和功能之间的双向关系.
研究的目的:
- 在CKD中提供肠轴的全面审查.
- 探索饮食,生物活性物质和营养保健品在调节肠道微生物群和支持脏健康方面的作用.
- 检查饮食干预措施在控制CKD进展方面的潜力.
主要方法:
- 文献综述侧重于肠-轴,肠道失调和CKD.
- 对饮食干预,功能成分,营养素和神经保护性植物成分的研究分析.
- 探索已确定的生物活性物质和新型营养药物,对脏健康有意义.
主要成果:
- 饮食选择深刻影响肠道微生物群,影响CKD的发展和进展.
- 由肠道微生物产生的尿性毒素通过炎症和氧化应激加剧损伤.
- 功能性食品和营养保健品通过向肠轴,显示出缓解CKD进展的潜力.
结论:
- 饮食干预对于通过调节肠道微生物群和减少尿素毒素的产生来管理CKD至关重要.
- 用特定的营养素和生物活性化合物准肠-轴为病提供了一个有前途的治疗策略.
- 对营养药和功能成分的进一步研究可以导致支持脏健康的新方法.
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