含有可持续制备的基于银的纳米材料的抗菌油凝用于局部应用
Valeria Ambrogi1, Morena Nocchetti1, Donatella Pietrella2
1Dipartimento di Scienze Farmaceutiche, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.
Journal of functional biomaterials
|January 26, 2024
概括
油凝中的新银纳米材料显示出对皮肤感染细菌的强烈抗菌活性. 这些安全,非细胞毒性配方为皮肤感染提供了有前途的治疗方法.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 皮肤病学 皮肤病学
背景情况:
- 皮肤感染对健康构成重大挑战,需要新的抗菌药物治疗.
- 油脂凝为局部应用提供了一种多功能配方基础.
- 基于银的纳米材料具有广泛的抗微生物特性.
研究的目的:
- 开发和描述用于抗微生物凝的银基纳米材料.
- 评估这些油脂凝对常见皮肤病原体的疗效.
- 评估开发的配方的安全性和非细胞毒性.
主要方法:
- 通过紫外线照射来可持续合成银复合材料.
- 使用TEM,SEM,ATR FT-IR和UV-Vis光谱光度学进行表征.
- 使用蒸二氧化作为凝剂制备油脂凝的配方.
主要成果:
- 银复合材料含有8-20纳米的球形纳米粒子.
- 复合材料显示出对*Pseudomonas aeruginosa*,*Staphylococcus aureus*和*Staphylococcus epidermidis*具有显著的抗菌活性.
- 由此产生的油脂凝表现出强大的抗菌作用,而不会对纤维细胞和角质细胞产生细胞毒性.
结论:
- 基于和银的油脂凝是治疗皮肤感染的有效抗菌剂.
- 化二氧化作为有效的双功能辅助剂用于纳米粒子支和凝.
- 这些新型油脂凝代表了皮肤感染的安全和有前途的治疗选择.
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