使用纳米技术软雾喷嘴芯片改善了理论素的嗅觉沉积
Madeline X Zhang1, Frank Verhoeven2, Pieter Ravensbergen2
1Van der Waals-Zeeman Institute, Institute of Physics, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Pharmaceutics
|January 26, 2024
概括
这项研究引入了一种新的纳米工程喷嘴,用于鼻腔药物输送,显著改善嗅觉区域的药物沉积,以更好地提供鼻至大脑输送. 新喷嘴的嗅觉覆盖率高达31.5%,超过了传统设备的性能.
科学领域:
- 纳米技术纳米技术
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 目前的鼻腔药物输送方法,如旋转喷嘴和注射器,在关键的鼻腔区域 (如嗅觉区域) 呈现有限的沉积.
- 嗅觉区域对于直接的鼻到脑药物输送至关重要,这种途径通常是神经治疗的目标.
研究的目的:
- 开发和评估一种纳米工程喷嘴芯片,用于增强鼻内药物输送,特别针对改善嗅觉区域的沉积.
- 为了比较新型纳米技术喷嘴的沉积效率与传统的旋转喷嘴设备.
主要方法:
- 制造和测试了两个纳米工程喷嘴芯片,具有不同微米大小的孔尺寸.
- 在体外沉积研究中,使用鼻腔模型进行了以受控的吸入流速 (0-25 L/分钟) 进行的theophylline配方.
- 一项用户研究评估了患者指令对吸入流速特征的影响.
主要成果:
- 纳米工程喷嘴在较低的羽毛速度下产生了较小的滴 (10-50μm),增强了沉积.
- 纳米技术喷嘴的嗅觉覆盖率从21.5%到31.5%不等,远高于传统旋转喷嘴在类似流速下达到的10.8%.
- 发现患者的指令会影响吸入速率的流量特征.
结论:
- 纳米技术软雾喷嘴显示出改善鼻内药物输送的巨大潜力,特别是增强关键嗅觉区域的沉积.
- 这项技术为针对性鼻至脑药物输送应用提供了有前途的进步.
- 以用户说明为指导,优化吸入流量是最大限度地利用这种新的输送系统的关键.
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