化学和开发脂质纳米颗粒的艺术用于生物药物交付:专注于开发和扩大规模
Rijo John1, Jasmin Monpara1, Shankar Swaminathan2
1Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Saint Joseph's University, Philadelphia, PA 19104, USA.
Pharmaceutics
|January 26, 2024
概括
脂质纳米粒子 (LNP) 是mRNA和蛋白质等生物学的先进载体. 本综述涵盖了用于药物输送的LNP技术,重点是治疗应用的脂质化学,制造和表征.
科学领域:
- 生物技术和制药科学 生物技术和制药科学
- 纳米医学和药物输送系统
- 化学工程和材料科学化学工程和材料科学
背景情况:
- 脂质纳米颗粒 (LNP) 是各种治疗剂的越来越重要的载体,包括蛋白质,核酸和信使RNA (mRNA).
- 生物药物已在临床实践中建立,人们对开发新型治疗变异越来越感兴趣.
- 现有的输送系统面临着大型生物分子的挑战,需要先进的配方策略.
研究的目的:
- 审查脂质纳米粒子 (LNP) 技术,以有效地提供生物制剂.
- 总结化学,制造和脂质的表征LNP配方的进展.
- 提供关于LNP技术在生物交付中的机遇和挑战的见解.
主要方法:
- 关于生物输送LNP技术的综合文献综述.
- 对LNP脂质的化学合成,制造工艺和表征技术的分析.
- 讨论LNP属性,包括大小,生物相容性和生物降解性,在治疗交付的背景下.
主要成果:
- 由于其有利的物理化学性质,LNP表现出在细胞内运输治疗成分方面的熟练程度,毒性和不良反应最小.
- 在化学和制造对于LNP发展至关重要的脂质方面取得了重大进展.
- 鉴定方法对于确保LNP在生物应用中的质量和有效性至关重要.
结论:
- 脂质纳米粒子技术为克服与生物制剂相关的交付挑战提供了一个有希望的策略.
- 在脂质化学,制造和表征方面的持续创新将进一步增强基于LNP的治疗系统.
- 解决LNP技术当前的挑战是释放其未来生物制药开发的全部潜力的关键.
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