各种聚乙烯聚合物的对美特罗尼达结晶过程的影响
Luiza Orszulak1, Taoufik Lamrani2, Magdalena Tarnacka2
1Institute of Chemistry, Faculty of Science and Technology, University of Silesia in Katowice, Szkolna 9, 40-007 Katowice, Poland.
Pharmaceutics
|January 26, 2024
概括
合成和研究了线性和星形聚乙烯罗利聚合物,以检测它们防止美트로尼达结晶的能力. 线性聚合物表现出更好的混合性和结晶抑制,而星形聚合物在特定比例下保持了无形性.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 聚烯 (PVP) 是一种多功能聚合物,用于各种应用,包括制药.
- 控制活性药物成分 (API) 的晶体行为,如甲 (MTZ) 对于药物的稳定性和生物可用性至关重要.
- 聚合物拓学可以影响药物-聚合物相互作用和由此产生的药物-聚合物混合物的固态特性.
研究的目的:
- 开发对线性 (linPVP) 和星形 (starPVP) 聚烯罗利的一步合成策略.
- 为了研究linPVP和starPVP作为抑制美트로尼达结晶的矩阵的潜力.
- 阐明聚合物拓在药物聚合物混合性和无形活性药物成分稳定中的作用.
主要方法:
- 精确定义的linPVP和starPVP的合成.
- 用各种PVP配方制备MTZ的二元混合物 (BMs).
- 使用里埃变换红外光谱法 (FTIR),差分扫描热度计 (DSC) 和X射线衍射 (XRD) 的表征.
主要成果:
- 在50:50重量比 (w/w) 时,LinPVP与MTZ表现出最大的混合性,而在30:70w/w时,starPVP也表现出混合性.
- 线性PVP在50:50和75:25 w/w比率下对抑制MTZ结晶产生最显著的影响.
- 在较高药物度下,星形PVP在稳定无形MTZ方面效果较差,但在MTZ-starPVP 30:70 w/w BM中维持了一个多月的完全无形性.
结论:
- 聚合物拓学显著影响PVP矩阵和美트로尼达之间的相互作用.
- 与星形PVP相比,在某些度下,线性PVP在抑制MTZ结晶方面更有效.
- 星形PVP在特定的配方条件下保持无形药物状态的独特优势,特别是在高药物负载下.
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