发酵多边形皮对骨肌肉功能的影响
Young-Seon Kim1,2,3, Ji-Hye Han3, Chang-Hoon Lim1,2,4
1Department of Medicinal Biosciences, College of Biomedical & Health Science, Konkuk University, 268, Chungwon-daero, Chungju 27478, Chungbuk, Republic of Korea.
Nutrients
|January 26, 2024
概括
用埃莫丁和白醇丰富的发酵多角 (Pc) 显著改善了小鼠的骨肌肉强度和运动功能. 这种发酵的植物提取物还增强了代谢健康,为肌肉疲弱提供了潜在的益处.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 植物提取物如Polygonum cuspidatum (Pc) 在功能性食品中被用于其健康益处.
- Pc含有有益的化合物,如黄类化合物, antraquinones 和 stilbenes.
- 发酵PC对骨肌肉健康的影响尚不清楚.
研究的目的:
- 研究发酵Pc (McPc) 对骨肌肉强度和运动功能的影响.
- 为了分析发酵后埃莫丁和白醇等关键化合物的变化.
- 探索McPc对肌肉和代谢健康的影响背后的分子机制.
主要方法:
- 使用微生物复合物发酵Pc,其中包括Lactobacillus spp. 为了创建McPc.
- 在McPc中使用UPLC-QTOF/MS和HPLC量化埃莫丁和白醇.
- 基因表达分析 (RNA-seq,qRT-PCR) 在C2C12神经管和小鼠胃角肌中.
- 在小鼠模型中评估肌肉强度,运动功能和代谢参数 (腹肌切除术,高脂肪饮食).
主要成果:
- 与未发酵的Pc相比,McPc显示出埃莫丁和白醇水平的增加.
- 麦克皮克调高了与抗氧化活性,能量代谢 (糖解,氧化酸化) 和线粒体生物发生相关的基因.
- 在小鼠的骨肌肉强度,运动协调和引力方面观察到显著的改善.
- 在高脂肪饮食养小鼠中,McPc的使用改善了肥胖,高血糖,脂肪肝和高脂血症.
结论:
- 发酵PC (McPc),富含埃莫丁和白醇,可以增强骨肌肉的强度和运动功能.
- McPc积极影响参与肌肉能量代谢和抗氧化剂防御的细胞通路.
- 这种发酵的提取物在骨肌肉衰弱和相关代谢障碍方面显示出潜在的治疗益处.
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