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评估COVID-19疫苗接种对早产的影响:通过元分析进行系统审查

Mihaela Uta^1,2, Marius Craina¹, Felicia Marc³

¹Discipline of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

|January 26, 2024

概括

在怀孕期间接种COVID-19疫苗是安全的,不会增加早产风险. 这项对六项研究的系统审查发现COVID-19疫苗和不良分娩结果之间没有显著的关联,支持在孕妇中使用疫苗.

科学领域:

产科和妇科产科和妇科
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

怀孕期间对COVID-19疫苗安全性,特别是早产风险的担忧一直很普遍.
现有数据需要综合,以告知临床实践和公共卫生建议.
过早分娩,定义为怀孕37周之前的分娩,是产科护理的一个重要问题.

研究的目的:

系统地审查和评估COVID-19疫苗接种对孕妇早产风险的影响.
为医疗保健提供者和政策制定者提供有关怀孕期间COVID-19疫苗接种的基于证据的信息.
评估COVID-19疫苗关于早产结果的安全概况.

主要方法:

按照PRISMA指南进行的系统审查和元分析,搜索PubMed,Embase和Scopus,直到2023年10月.
纳入标准集中在检查COVID-19疫苗接种在怀孕和早产相关性的研究上.
分析了6项涉及35,612名患者的研究,评估了研究质量和偏差风险.

主要成果:

对六项不同研究 (以色列,罗马尼亚,美国) 的元分析显示,在接种疫苗后的早产中,总的几率比率为1.03 (95% CI:0.82-1.30),表明没有显著的增加.
研究中的低异质性 (Cochran's Q = 2.10,I2 = 13%) 表明研究结果一致.
新生儿结局,包括出生体重和APGAR分数,在接种疫苗和未接种疫苗的组之间显示出极小的差异.

结论:

怀孕期间的COVID-19疫苗接种与早产风险的显著增加无关.
研究结果支持COVID-19疫苗对孕妇及其胎儿的安全性.
这些结果强化了COVID-19疫苗接种作为流行病期间的公共卫生战略的重要性.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.怀孕怀孕怀孕怀孕怀孕接种疫苗接种疫苗

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