推进药物输送范式:基于聚烯酸 (PVP) 的无形固体分散,以提高物理化学性能和治疗效率
Agus Rusdin1,2, Amirah Mohd Gazzali3, Nur Ain Thomas4
1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjadjaran, Jl. Raya Bandung-Sumedang Km-21, Bandung 45363, Indonesia.
Polymers
|January 26, 2024
概括
基于聚烯 (PVP) 的无形固体分散剂 (ASDs) 有效地提高了难以溶解药物的溶解性和生物可用性. 这次审查强调了PVP的重点.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 物理化学挑战,例如溶解性差,限制了药物的有效性和生物可用性.
- 无形固体分散 (ASD) 是克服这些可溶性限制的关键策略.
- 聚烯 (PVP) 越来越多地被认为具有提高药物物理化学性能的潜力.
研究的目的:
- 审查基于PVP的ASD的开发和应用,以改善药物溶解性和生物制药性能.
- 专注于PVP作为一种用于先进药物配方的新型辅助剂.
- 总结目前关于PVP在无形固体分散技术中的研究.
主要方法:
- 自2018年以来,对Scopus,PubMed和谷歌学者数据库进行了全面的文献搜索.
- 适用于选择相关科学文章的包含和排除标准.
- 对以PVP为基础的无形固体分散的研究进行系统审查.
主要成果:
- PVP在提高难溶性药物的可溶性和生物利用性方面表现出显著的有效性.
- 讨论了基于PVP的ASD的各种制备技术,包括溶剂蒸发,融火,电,共降和球磨.
- 通过各种准备方法,可以实现ASD的定制特征.
结论:
- 基于PVP的ASD为不容易溶解的药物的配方,稳定性和性能提供了巨大的好处.
- 这些系统可以显著提高药物的总体生物可用性.
- 这些发现支持在开发量身定制的自闭症障碍症方面取得进一步的进展,以提高药物疗效.
相关概念视频
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