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David Brefeld1, Valentina Di Mauro1, Matthias Y Kellermann1

  • 1Environmental Biochemistry Group, Institute for Chemistry and Biology of the Marine Environment (ICBM), School of Mathematics and Science, Carl von Ossietzky University of Oldenburg, Ammerländer Heerstraße 114-118, 26129 Oldenburg, Germany.

Toxics
|January 26, 2024
PubMed
概括

开发了一种新的珊瑚毒性测试方法,以评估影响珊瑚礁构建珊瑚的化学污染物. 白化和死亡率是农药和个人护理产品等物质的敏感指标.

关键词:
紫外线过器 紫外线过器生态毒理学 生态毒理学个人护理产品 个人护理产品杀虫剂 杀虫剂 杀虫剂斯克莱拉克提尼亚 斯克莱拉克提尼亚标准化 标准化 标准化试验方法 试验方法毒性的毒性 毒性的毒性

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...