在生活在受污染地区的健康年轻男子中,多二和精液质量

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Francesco Donato¹, Matteo Rota², Elisabetta Ceretti¹

¹Unit of Hygiene, Epidemiology and Public Health, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy.

|January 26, 2024

概括

精液中高水平的多二 (PCB) 对精子运动和正常形态产生负面影响. 血清PCB水平与意大利年轻男性的精液质量存在不一致的关联.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
生殖生物学生殖生物学

背景情况:

多双 (PCB) 是持久性有机污染物,具有内分泌干扰性.
之前对PCB和人类精液质量的研究已经产生了相互矛盾的结果.
了解PCB暴露对生殖健康的影响至关重要,特别是在污染地区.

研究的目的:

调查血清和精液PCB含量与年轻男性的精液质量参数之间的关联.
评估特定PCB同源和总PCB对精子运动性,度和形态学的影响.
根据血清中的PCB含量与精液中的PCB含量来评估潜在的关联差异.

主要方法:

一项涉及143名男性学生 (18-22岁) 的横截面研究,来自意大利一个受PCB污染的地区.
在血清和精液样本中测量26种PCB同源物,功能组和总PCB,使用气色谱-质谱法.
精液参数分析,包括精子度,总运动率和正常形态.

主要成果:

精液中PCB总度升高与精子总运动率降低 (降低高达19%) 和正常形态 (降低高达23%) 有关.
精液中的特定PCB原体和总PCB显示出与精子运动性和形态学的负面关联.
血清PCB含量与精液质量参数之间的关联不一致,结果为零或混合.

结论:

这项研究提供了证据,证明精液中存在的PCB会对精子运动和正常形态产生负面影响.
在这种人群中,精液PCB水平似乎比血清水平更一致地表明对精子质量的不良影响.
需要进一步的研究来澄清血清和精液PCB水平之间的复杂相互作用及其对男性生殖健康的具体影响.

关键词:

持久性有机污染物持久性有机污染物聚二乙烯的多化物.精液质量精液质量精液质量精子度精子度精子度精子运动性精子运动性精子的正常形态是正常的.

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