净水吸收作为急性缺血性中风结果的预测神经成像标志物:一个元分析
Sherief Ghozy1,2, Melika Amoukhteh1,3, Alireza Hasanzadeh4
1Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
European radiology
|January 26, 2024
概括
在CT扫描上测量的净吸水量 (NWU) 是预测急性缺血性中风 (AIS) 患者预后的有希望的生物标志物. 较高的NWU水平与较差的结果相关,这表明其潜在的临床实用性.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 生物标志物发现发现
背景情况:
- 急性缺血性中风 (AIS) 构成了重大的健康挑战,需要准确的预后工具.
- 早期检测和预测AIS的结果对于及时有效的患者管理至关重要.
研究的目的:
- 评估净吸水量 (NWU) 在确定AIS患者的结果中的预测作用.
- 综合现有关于NWU的证据作为AIS中的预后标记.
主要方法:
- 一项系统性审查和对报告入院AIS患者CT扫描中的定量NWU的研究的元分析.
- 在主要数据库 (PubMed,Scopus,Web of Science,Embase) 搜索到2023年7月.
- 分析了17项涉及2217名AIS患者的研究数据,使用了R.软件.
主要成果:
- 在AIS患者中,NWU显著更高,结果较差,与结果良好患者相比 (p < 0.001).
- 升高的NWU与功能性结果差 (mRS),恶性胀/心脏病发作和内出血有关.
- 尽管排除了一个异常值,但在研究中仍然存在显著的异质性 (I2 = 90.8%).
结论:
- 基于CT的NWU显示了作为AIS中各种结果的预测生物标志物的潜力.
- 建议在前性多中心试验中进行标准化,自动化的NWU测量,以获得可靠的验证.
- 进一步的研究可能有助于将NWU纳入临床实践,以改善AIS患者护理.
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