在异常性复发性心膜炎中Anakinra:一个全面的病例系列和文献综述
Zeynep Toker Dincer1, Sejla Karup2, Erkin Yilmaz2
1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey.
Zeitschrift fur Rheumatologie
|January 26, 2024
概括
作为一种干白素-1 抑制剂的阿纳金拉有效治疗抗标准治疗的异常性复发性心膜炎 (IRP). 这种疗法显著降低了炎症,并允许大多数患者停止使用类固醇.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 异常性复发性心膜炎 (IRP) 涉及未知原因的重复性心膜炎炎症.
- 传统的治疗方法,如NSAIDs,皮质类固醇和胆固醇并不总是有效的.
研究的目的:
- 为了调查安卡尼拉 (anakinra) 的安全性和有效性,这是一种干白素-1 抑制剂.
- 评估阿纳金拉作为治疗常规疗法耐药的IRP患者的治疗方法.
主要方法:
- 在2011年至2023年期间接受治疗的21名IRP患者的回顾性评估.
- 查单源性自身炎症性疾病 (MEFV,TRAPS,MVK,NLRP3,NOD2) 的情况.
- 在对标准护理无反应的患者中评估阿纳金拉治疗反应.
主要成果:
- 16名患者中有15名成功停止了类固醇治疗.
- 在阿纳金拉治疗后,C-反应蛋白 (CRP) 水平从196 mg/l显著降低到2.6 mg/l.
- 四名患者 (19.0%) 经历了轻微的注射部位反应.
结论:
- 阿纳金拉是对IRP的有希望的治疗方法,特别是在耐固醇病例中.
- 这项研究支持介素-1 抑制剂在IRP管理中的有效性.
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