对于胃癌的区域治疗方法与有限的腹腔疾病
Amy Y Li1, Shaina Sedighim1, Fatemeh Tajik1
1Department of Surgery, University of California, Irvine, 3800 Chapman Ave, Ste 7400, 92868, Orange, CA, USA.
Journal of gastrointestinal cancer
|January 26, 2024
概括
腹腔内 (IP) 化疗,包括加热 (HIPEC),正常热 (NIPEC) 和压力气溶 (PIPAC) 方法,对胃癌腹腔内癌 (GCPC) 有希望. 在选定的患者中,将IP疗法与细胞还原性手术 (CRS) 结合起来,可能会显著提高生存率.
科学领域:
- 胃肠道学和瘤学
- 手术瘤学手术瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃癌腹癌 (GCPC) 由于系统治疗透率有限,结果不佳.
- 用腹腔内 (IP) 化疗进行区域治疗为GCPC管理提供了一个有前途的替代方案.
研究的目的:
- 审查区域IP治疗方法的高级证据,以管理有限的腹膜疾病的GCPC.
- 评估各种IP化疗模式的疗效与细胞减小手术 (CRS) 结合使用.
主要方法:
- 对III期RCT,II期研究和高影响力回顾性研究的综合文献综述.
- 将IP疗法的正在进行的临床试验数据纳入GCPC.
- 分析不同的IP化疗方式:HIPEC,NIPEC和PIPAC.
主要成果:
- 当与全身疗法和/或CRS相结合时,HIPEC,NIPEC和PIPAC显示出有希望的结果.
- 有证据表明,GCPC患者的生存率和腹疾病控制有所改善.
- 患者选择,优化全身疗法和完整的细胞减少对于试验成功至关重要.
结论:
- 内化疗,特别是当与精选的GCPC患者的CRS相结合时,可以显著改善存活率.
- 目前和未来的临床试验预计将进一步完善GCPC的治疗模式.
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