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激活MC4R通过抑制氧化应激介导的AIM2激活后脊髓损伤促进功能恢复

Yongli Wang1,2, Nongtao Fang1, Yikang Wang1

  • 1Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Molecular neurobiology
|January 26, 2024
PubMed
概括

黑色皮质素受体4 (MC4R) 的激活有助于通过减少氧化应激和炎症来恢复脊髓损伤 (SCI). 这一途径涉及抑制AIM2激活和维持线粒体功能,为SCI提供了潜在的治疗策略.

关键词:
在黑色素瘤2缺席.黑色素皮质蛋白受体4 黑色素皮质蛋白受体4线粒体中的线粒体.脊髓损伤导致的脊髓损伤

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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