未经治疗的前性精神病和认知障碍的持续时间
TianHong Zhang1, HuiRu Cui1, YanYan Wei1
1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
JAMA network open
|January 26, 2024
概括
未经治疗的前兆症状 (DUPrS) 的持续时间较短与临床精神病风险较高的个体的认知功能较差有关. 这凸显了DUPrS和认知在预测精神病风险方面的重要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 未经治疗的前兆症状 (DUPrS) 持续时间和精神病临床高风险 (CHR) 个体的认知功能之间的关联尚未得到充分理解.
- 了解这种关系对于预测精神病风险和指导干预至关重要.
研究的目的:
- 调查DUPrS,认知表现和CHR个人转化为精神病之间的相互作用.
- 为了确定DUPrS是否影响认知轨迹和精神病风险.
主要方法:
- 在CHR进行了一项针对精神病的506人队列研究.
- 参与者接受了基线神经心理评估和3年的临床随访.
- 分析了DUPrS,认知变量和转换风险,使用定量和考克斯比例危险回归.
主要成果:
- 较短的DUPrS (≤3个月) 和中位数的DUPrS (4-9个月) 与较长的DUPrS (≥10个月) 相比,在视觉空间记忆和类别流利性测试中的表现较差.
- 较低的教育程度,负面症状和特定认知测试 (Mazes,BVMT-R) 的受损表现预测转化为精神病.
- 20.8%的参与者在3年内转化为精神病.
结论:
- 这项研究表明,DUPrS,认知功能和转化为精神病的风险之间存在显著的相互作用.
- 考虑DUPrS和认知状态对于评估CHR中个人的精神病发展轨迹很重要.
- 这些发现强调了早期干预的必要性,以减少DUPrS和管理认知缺陷.
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