关于美国成年人自我报告的 Kratom 使用,影响和动机的生态瞬间评估
Kirsten E Smith1,2, Leigh V Panlilio1, Jeffrey D Feldman1,2
1Real-World Assessment, Prediction, and Treatment Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland.
JAMA network open
|January 26, 2024
概括
数以百万计的人使用克拉来缓解疼痛和情绪,但这项研究显示,更高的使用与身体依赖有关. 避免戒断成为有问题的kratom使用的关键动机,突出了进一步研究的需要.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 克拉 (Mitragyna speciosa) 被广泛用于缓解疼痛,改善情绪和自我管理物质使用障碍 (SUD).
- 现有的研究很大程度上依赖于调查,可能受到回忆偏差的影响,需要更客观的研究方法.
- 了解 kratom 使用的实时动机和影响对于公共卫生和临床实践至关重要.
研究的目的:
- 描述Kratom的近接动机,即时效应和使用模式.
- 评估使用kratom频率与动机之间的关联,经历的影响以及使用kratom障碍 (KUD) 的标准.
- 探索 kratom 使用与使用其他物质之间的关系.
主要方法:
- 一项前性,横截面研究,利用基于智能手机的15天的生态瞬间评估 (EMA).
- 参与者 (N=357) 是美国成年人,在4周内至少每周3天使用kratom.
- 欧洲药物管理局捕获了关于kratom使用事件,动机,短期影响,情绪和日常经验的实时数据;贝叶斯回归分析了数据.
主要成果:
- 卡拉使用的近距离动机包括增加能量,生产力和减少疼痛,与基线报告的原因不同 (管理精神病/SUD问题).
- 急性影响通常被认为与日常活动相容;使用模式各不相同,但通常以白天使用为中心.
- 较高的kratom使用频率与身体依赖症状 (戒断,耐受性) 有关;常见的共同使用物质包括咖啡因,尼古丁和大麻.
结论:
- 大多数参与者报告说,使用kratom没有问题,而戒断避免在使用变得有问题时成为主要驱动因素.
- 这项研究突出了kratom动机和实时效应的动态性质.
- 进一步的纵向研究对于了解 kratom 使用模式的变化及其长期影响至关重要.
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