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ELMO1基因多态和糖尿病病之间的关联:系统性审查和元分析
Alireza Azarboo1,2, Shaghayegh Hosseinkhani3, Amirhossein Ghaseminejad-Raeini1,2
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
PloS one
|January 26, 2024
概括
在ELMO1基因,特别是rs741301,rs1345365,rs10255208和rs7782979中的遗传变异与糖尿病病 (DKD) 易感性有显著联系. 这种联系在中东人口中尤为明显.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症,导致慢性病和末期病.
- 在此之前,ELMO1基因已与DKD的发病因子有关.
研究的目的:
- 系统地审查和分析ELMO1基因多态和DKD之间的关联.
- 为潜在的个性化医疗应用提供高水平的证据.
主要方法:
- 从1980年到2023年1月,在主要数据库 (PubMed,Scopus,EMBASE,Web of Science) 进行了系统的文献搜索.
- 使用适当的统计模型计算了聚合赔率比率和置信区间.
- 进行了子组和灵敏度分析,以评估异质性和稳定性.
主要成果:
- 该审查包括17项研究,包括5794名DKD患者,4886名没有DKD的糖尿病患者和2023名健康对照.
- ELMO1 rs741301的多态性在主导型,同位素型和衰退型模型下与DKD易感性有显著的关联.
- 在等位基模型下,多态 rs1345365,rs10255208和rs7782979与DKD有显著的关联.
- 在中东人口小组中,DKD风险明显更高.
结论:
- ELMO1 rs741301的多态性与DKD易感性有显著的联系.
- 其他ELMO1多态 (rs1345365,rs10255208,rs7782979) 也与DKD有显著的关联.
- 这些发现突显了ELMO1基因多态性对个性化医疗方法在管理DKD的潜力,特别是在中东人口中.
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