PhyloString:一个旨在识别,可视化和评估不同族系遗传系中正统蛋白质组之间的功能关系的Web服务器
Claudia Dorantes-Torres1, Maricela Carrera-Reyna1, Walter Santos1
1Department of Molecular Microbiology, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
PloS one
|January 26, 2024
概括
PhyloString可视化了跨物种的蛋白质功能网络. 它基于STRING数据库相互作用和家族遗传起源来识别凝聚性蛋白质模块,帮助进行比较分析.
科学领域:
- 生物信息学是一种生物信息学.
- 系统生物学 系统生物学
- 计算生物学 计算生物学
背景情况:
- 蛋白质是具有多种功能 (酶,结构,调节) 的基本生物单元.
- 了解蛋白质的功能关系对于破译生物过程至关重要.
- 像STRING数据库这样的现有资源为模型生物提供了蛋白质-蛋白质相互作用网络.
研究的目的:
- 开发一个Web服务器,PhyloString,用于识别和可视化不同物种的蛋白质功能网络.
- 为了使这些网络能够分解成基于相互作用强度和家族遗传起源的凝聚性模块.
- 促进对不同生物体的功能网络和蛋白质模块进行比较分析.
主要方法:
- 使用了来自STRING数据库的索引.
- 开发了PhyloString网络服务器 (https://biocomputo.ibt.unam.mx/phylostring/).
- 实施了一个基于STRING相互作用得分和族系遗传数据的模块分解策略.
主要成果:
- 成功开发和部署了PhyloString网络服务器.
- 证明了蛋白质功能网络的识别和可视化.
- 展示了网络的分解成生物相关的模块.
- 介绍了功能性网络和模块的例子,这些模块可以在不同的基因谱系中识别.
结论:
- PhyloString有效地促进了多种生物体中蛋白质功能网络和模块的识别,可视化和评估.
- 模块分解方法有助于理解保存和分离的蛋白质相互作用模式.
- PhyloString是比较系统生物学研究的一个有价值的工具.
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