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Updated: Jul 4, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

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错误拼接的转录在与TDP-43相关的ALS/FTD中产生新的蛋白质

Sahba Seddighi1,2, Yue A Qi3, Anna-Leigh Brown4

  • 1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Science translational medicine
|January 26, 2024
PubMed
概括

丢失TDP-43蛋白质会导致神秘的外,从而导致神经元和患者体液中的新蛋白质. 这一发现提供了关于肌缩侧面硬化症 (ALS) 和前性痴呆症 (FTD) 疾病机制的见解.

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