在RBANS延迟记忆指数上重新选? 忘记了这些!
Marwan N Sabbagh1, Wojciech Michalak2, Charlotte Thim Hansen3
1Department of Neurology, Barrow Neurological Institute, Phoenix, AZ.
Alzheimer disease and associated disorders
|January 26, 2024
概括
重新选阿尔茨海默氏症患者最初在神经心理状态延迟记忆指数 (RBANS DMI) 评估重复电池上的得分较低,具有有限的价值. 大多数患者没有表现出显著的认知衰退,也没有满足进一步评估的标准.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 临床心理学 临床心理学
背景情况:
- 阿尔茨海默病 (AD) 诊断依赖于认知评估.
- 神经心理状态延迟记忆指数 (RBANS DMI) 的可重复电池评估是一个关键的认知指标.
- 重新查边界RBANS DMI得分的患者的实用性尚未得到充分证实.
研究的目的:
- 评估重新查阿尔茨海默病患者的临床价值,这些患者最初不符合RBANS DMI的纳入标准.
- 为了确定最初的RBANS DMI得分是否预测未来的认知能力下降或生物标志物阳性.
主要方法:
- 来自欧洲预防阿尔茨海默氏症痴呆症数据库的数据分析.
- 包括50-85岁没有痴呆症的参与者,迷你精神状态检查得分≥22,和基线粉样蛋白状况.
- 利用重复测量和后勤回归的混合效应模型来分析RBANS DMI得分的变化和进展.
主要成果:
- 观察到RBANS DMI得分随时间变化的显著变化.
- 大约15%的参与者基线RBANS DMI得分在86-95之间,在6个月后进展到≤85.
- 在那些进展的患者中,8%的人还符合临床痴呆症评分总分≥0.5的标准,5%是粉样蛋白阳性.
结论:
- 仅根据最初的RBANS DMI得分重新选患者具有有限的诊断或预后价值.
- 这些发现表明,目前针对阿尔茨海默病的重新选协议可能无法优化,对于边界初始认知测试结果的患者来说.
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