血管的三维 (生物) 打印:从血管化组织到功能性动脉
Shubham Makode1, Satyajit Maurya1, Seyed A Niknam2
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
Biofabrication
|January 26, 2024
概括
组织工程利用生物打印来创建人工血管,用于治疗血管疾病并改善工程组织的生存. 本综述探讨了用于血管移植制造和整合的生物打印技术.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
背景情况:
- 血管功能障碍影响了许多慢性疾病和组织工程的成功.
- 工程血管对于替换患病的血管和将工程组织与宿主循环相结合至关重要.
- 生物打印为仿生结构制造提供了对细胞和矩阵沉积的精确控制.
研究的目的:
- 审查影响血管的条件和人工血管移植的需要.
- 讨论与组织工程相关的血管解剖学和生理学.
- 探索和比较用于血管组织工程的3D生物打印技术.
主要方法:
- 关于血管疾病和组织工程策略的文献综述.
- 对用于血管结构制造的3D生物打印技术的分析.
- 基于能力和应用的不同生物打印技术的比较.
主要成果:
- 生物打印可以在工程组织中精确地制造独立的血管移植和复杂的血管结构.
- 生物材料和印刷控制方面的进步提高了功能性血管结构的发展.
- 各种3D生物打印技术为血管组织工程应用提供了明显的优势.
结论:
- 3D生物打印是一种强大的工具,用于创建功能性血管移植和集成血管系统.
- 对生物打印技术和生物材料的进一步研究将推动血管组织工程.
- 未来的机遇在于优化生物打印以实现复杂的血管网络再生.
相关概念视频
Anatomy of the Circulatory System
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Overview of the Vascular System
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Overview of Blood Vessels
The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
Structure of Blood Vessels
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Anatomy of Blood Vessels
The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...


