在生物样本中检测butan,propan及其代谢物的分析方法:对吸入药物滥用检测的影响
Jihyun Kim1, Sanggil Choe2, Ilchung Shin3
1Forensic Toxicology & Chemistry Division, Seoul Institute, National Forensic Service, Seoul 08036, Republic of Korea; Department of Pharmaceutical Analysis, College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea.
概括
这项研究开发了在生物样本中检测,及其代谢物的方法. 暴露后几个小时内在尿液中发现了代谢物,证实了吸入剂的滥用.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
背景情况:
- 吸入和等挥发性物质的滥用是全球关注的问题.
- 这些物质的快速消除需要代谢物分析来检测.
研究的目的:
- 开发对,及其代谢物进行分析方法.
- 确定检测窗口和曝光指标.
主要方法:
- 使用了头空间-气体染色学-质谱学 (GC-MS) 和固相微提取-GC-MS.
- 在血液和尿液中分析了异布,n-布,和9种代谢物.
- 进行了动物研究,并分析了人类尿样.
主要成果:
- 在血液中短暂检测到母化合物;在暴露后长达5小时内,可以在尿液中检测到代谢物.
- 确定了关键代谢物,如2 - 甲基 - 2 - 醇,2 - butanol,2 - butanone,乙,乙,和2,3-butanediol异构体.
- 通过代谢物识别确认吸入剂滥用.
结论:
- 建立了可靠的方法来检测丁,及其代谢物.
- 代谢物分析为确认吸入剂滥用提供了一个可行的窗口.
- 调查结果有助于法医调查和对挥发性物质滥用的临床评估.
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