[与长期COVID相关的遗传因素]
E J Gamero-de-Luna1, M R Sánchez-Jaén2
1Medicina Familiar y Comunitaria, Centro de Salud El Juncal, Sevilla, España; GT Medicina Genómica Personalizada y Enfermedades Raras, SEMERGEN, España.
Semergen
|January 26, 2024
概括
遗传因素影响COVID-19的严重程度和长期COVID的发病. 虽然一些基因与疾病严重程度有关,但长期COVID的特定遗传贡献者仍然不清楚,需要进一步研究多基因和表观遗传因素.
科学领域:
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 仅仅临床因素并不能完全解释COVID-19的变异性;遗传影响是显著的.
- 遗传因素对COVID-19易感性和严重性的作用已知,但它们对长期COVID发病和进展的参与尚不清楚.
- 了解遗传因素对于解释COVID-19的各种临床表现及其持久症状至关重要.
研究的目的:
- 系统地审查现有文献,并确定与持续性COVID-19 (长期COVID) 开始相关的遗传因素.
- 综合当前关于长期COVID遗传基础的知识.
- 突出研究中关于长期COVID的遗传贡献的差距.
主要方法:
- 通过PubMed,bioRxiv和medRxiv.com进行了科学文献的系统审查.
- 搜索策略使用了MeSH描述符和与COVID-19和遗传因素相关的术语.
- 最初对2715篇文章进行选,结果有205篇感兴趣的文章,最终选择了85篇文章进行详细审查.
主要成果:
- 与COVID-19易感性相关的ACE2和TMPSS6等基因没有被发现与长期COVID有关.
- 参与炎症和免疫反应的基因与疾病严重程度和长期COVID发作有关.
- FOXP4位点与长期COVID的发展有着特别有趣的关联.
结论:
- 目前已确定的遗传因素不能完全解释长期COVID的进展和发病.
- 需要进一步的研究来探索长期COVID中的多基因作用,类基因,微生物群和表观遗传变化.
- 对长期COVID的研究不足以充分理解其复杂的病因学.
关键词:
在COVID期间,长时间的COVID遗传现象是一种遗传现象.遗传现象是一种遗传现象.遗传变异 遗传变异 遗传变异长时间的COVID.简单的核子多重形态.后急性COVID-19综合征是什么后急性SARS-CoV-2的情况在感染SARS-CoV-2病毒后的严重后果.单个核酸的多态性.这就是COVID-19的Posagudo综合征.遗传变异是一种遗传变异.更多相关视频
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