酵素诱导抗发作药物的使用趋势:发作成年人的回顾性分析
Revital Gandelman-Marton1, Jacques Theitler1
1Neurology Department, Shamir-Assaf Harofeh Medical Center, Zerifin, Israel; Faculty of Medicine, Tel Aviv University, Israel.
Epilepsy & behavior : E&B
|January 26, 2024
概括
强效酶诱导抗发作药物 (EIASM) 在患者中的使用在过去十年中显著下降. 需要进一步努力来减少EIASM的使用,特别是在长期患有焦点的男性中.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 治疗的方法 治疗
背景情况:
- 诱导酶的抗发作药物 (EIASM) 与副作用和药物相互作用有关.
- 指导方针建议在初始治疗中优先考虑非EIASM.
- 对于已经使用EIASM的患者,建议评估从EIASM切换到非EIASM.
研究的目的:
- 评估在患者初次诊所访问期间使用强效EIASM的效果.
- 在十年内追踪强烈EIASM使用趋势.
主要方法:
- 一个10年的数据库 (2012-2021) 的门诊所访问的回顾性审查.
- 对730名服用抗发作药物 (ASM) 的患者的病历分析.
- 确定接受强效EIASM的患者 (243,33%).
主要成果:
- 每年的强效EIASM使用率从2012年的35.1%下降到2021年的11.8%.
- 在2012-2015年期间访问的患者中,与以后几年相比,观察到较高的EIASM使用率.
- 服用强效EIASM的患者年龄较大,更可能是男性,疾病持续时间较长,神经精神疾病并发症率较高,使用更多的ASM.
结论:
- 在治疗中,强大的EIASM利用在过去十年中呈现下降趋势.
- 需要继续努力,以尽量减少所有ASM治疗患者的EIASM使用.
- 应特别关注在患有焦点和疾病持续时间超过10年的男性中减少EIASM的使用.
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