IL-6是冠状病毒疾病2019相关心力衰竭的预测因子和潜在治疗点:单中心回顾性研究
1Department of General Practice, Tongji Hospital, School of Medicine, Tongji University, Shanghai 20065, China.
Cytokine
|January 26, 2024
概括
升高的IL-6水平与2019年新冠肺炎 (COVID-19) 患者的心力衰竭 (HF) 有显著联系. 这一发现突出了IL-6作为COVID-19相关高血压的关键炎症标志物.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 炎症在2019年冠状病毒病 (COVID-19) 相关的心力衰竭 (HF) 中发挥着作用,但潜在的机制需要进一步阐明.
- 与COVID-19相关的高血压相关的特定炎症因子的关联仍然不清楚.
研究的目的:
- 研究特定炎症因素与COVID-19患者心力衰竭的发生之间的关系.
- 为了确定与COVID-19相关的心力衰竭相关的关键炎症标志物.
主要方法:
- 在2022年3月至5月期间住院的212名成年COVID-19患者的回顾性研究.
- 炎症标志物的比较,包括interleukin-6 (IL-6),高灵敏性C反应蛋白 (hs-CRP) 和prokalcitonin (PCT),在患有和没有HF的患者之间.
- 后勤回归分析以确定炎症因素和HF之间的关联.
主要成果:
- 与没有高风的患者相比,COVID-19相关的高风患者在性别,年龄,hs-CRP,PCT和IL-6水平上表现出显著的差异.
- 后勤回归显示IL-6水平和HF之间存在显著的正相关性 (odds比=1.055,p<0.005).
- 高龄,高hs-CRP和高IL-6水平与高风险增加有关.
结论:
- 干白素-6 (IL-6) 的水平增加与COVID-19患者的心力衰竭有显著的关联.
- IL-6可能成为预测或理解COVID-19相关心力衰竭的关键炎症生物标志物.
相关概念视频
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
431
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
431
01:20The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:26Heart Failure Drugs: Inotropic Agents
588
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
588