前列腺体表达和肠上皮质屏障功能的改变在伊利乌斯
Anne Bessard1, Claire Cardaillac2, Thibauld Oullier1
1CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, IMAD, Nantes Université, Nantes, France.
The Journal of surgical research
|January 26, 2024
概括
在术后阴道 (POI) 中的肠道操纵改变了前列腺水平,15-脱氧-三角形12,14-前列腺素J2的减少导致了肠道功能障碍. 这表明,准这些前列腺素可能会恢复POI的屏障功能.
科学领域:
- 胃肠病学 胃肠病学
- 外科手术炎症 在外科手术炎症.
- 前列腺体生物化学 前列腺体生物化学
背景情况:
- 肠道操纵 (IM) 可以诱导炎症,可能导致手术后阴道 (POI).
- 前列腺状路径与POI病理生理学有关.
- 了解前列腺瘤的参与对于POI管理至关重要.
研究的目的:
- 在小鼠POI模型中描述前列腺形状和合成酶表达.
- 为了确定改变的前列腺素是否有助于POI相关的胃肠道 (GI) 功能障碍.
- 调查POI中特定的前列腺类药物的治疗潜力.
主要方法:
- 在IM后的小鼠中评估了GI运动性和肠上皮屏障 (IEB) 透性.
- 使用液体染色学-并联质谱法来分析多不和脂肪酸代谢物.
- 在体内给予前列腺类药物以评估它们对IM诱导的肠道功能障碍的影响.
主要成果:
- IM显著增加了阴过渡时间和IEB的透性.
- 在IM后14小时内,前环素合成酶和血液形成性前腺素-D合成酶表达和产物减少.
- 15-deoxy-delta 12,14-Prostaglandin J2降低了IEB的透性,而PGI2则加剧了IM引起的肠道功能障碍.
结论:
- 阿拉基酸衍生物在POI中对肠道功能障碍产生差异性影响.
- IM后15-脱氧-三角形12,14-前列腺素J2水平降低可能导致肠道功能受损.
- 针对15-deoxy-delta 12,14-Prostaglandin J2可能是POI相关屏障功能障碍的治疗策略.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.3K
06:31Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
Published on: June 2, 2023
1.0K
相关概念视频
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
430
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
430
01:21Inflammatory Bowel Disease V: Surgical Management
147
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
147
01:17Irritable Bowel Syndrome I: Introduction
276
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
276
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
186
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
186
01:17Chronic Bowel Disorders: Introduction
450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
01:23Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K