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雌醇和开始性微生物菌株调节了多发性硬化症中先天性淋巴细胞的功能活动

Irina Nekrasova¹, Natalia Glebezdina¹, Irina Maslennikova²

¹Perm Federal Research Center UB RAS, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Goleva str., 13, Perm 614081, Russia.

Multiple sclerosis and related disorders

|January 26, 2024

概括

怀孕激素雌醇和肠道细菌对多发性硬化症 (MS) 的先天性淋巴细胞 (ILC) 产生影响. 这些因素会改变ILC亚型和细胞因子的产生,这可能会影响MS的发病性.

科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
内分泌学在内分泌学.

背景情况:

多发性硬化症 (MS) 是一种针对髓蛋白的自身免疫性神经退行性疾病.
先天性淋巴细胞 (ILCs) 越来越多地被认为在MS病变发生过程中的作用.
怀孕与Th1-介导的自身免疫性疾病 (如MS) 的抑制有关.

研究的目的:

与健康捐赠者相比,研究MS患者ILCs的表型特征.
评估怀孕激素乙醇 (E3) 和开始性菌群对ILCs的影响.
了解这些因素是如何调节ILC成熟和细胞因子的.

主要方法:

用醇 (E3) 和细菌菌株 (大肠杆菌K12,乳酸菌植物8R-A3) 化ILCs,持续48小时.
使用单克隆抗体染色进行流细胞计分析,以评估ILC表型.
在MS患者和健康捐赠者之间比较ILC反应.

主要成果:

雌醇 (E3) 和细菌因素对ILC亚型的成熟和细胞因子的产生有不同的调节.
这些因素诱导ILC的表型变化,促进亚型之间的过渡.
在健康捐赠者和多发性硬化症患者中观察到的效应.

结论:

雌醇和开始性微生物群可以调节先天性淋巴细胞表型和功能.
这些调制可以提供有关MS背后的机制的见解,特别是关于与怀孕相关的变化.
对激素和微生物因素对ILC调节的进一步研究对于MS治疗策略是有必要的.

关键词:

美国大肠杆菌 (E. coli).埃斯醇是一种醇.天生的淋巴细胞是先天性淋巴细胞.在L. plantarum的研究中.多发性硬化症是多发性硬化症.

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