无药物情感障碍患者的甲状腺静止
Taizhen Cui1, Zhenyong Qi2, Mengwei Wang3
1The Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital), Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, Xinxiang 453002, China; School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China; Xinxiang Key Laboratory of Clinical Psychopharmacology, Xinxiang Medical University, Xinxiang 453003, China.
Psychoneuroendocrinology
|January 26, 2024
概括
情感障碍显示甲状腺全静止变化,降低了神代酶活性和甲状腺激素结合,但稳定的中央设定点. 躁狂可能会增加甲状腺分泌能力.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 代谢研究研究 代谢研究
背景情况:
- 甲状腺静止对于维持生理平衡至关重要.
- 情感障碍,包括主要抑郁症和双相情感障碍,可能涉及甲状腺功能障碍.
- 在这些条件下了解甲状腺静止对于潜在的治疗点至关重要.
研究的目的:
- 在没有药物治疗的患有情绪障碍的患者中研究甲状腺静止.
- 为了比较患有严重抑郁症,双相情感障碍,精神分裂症和健康对照患者之间的甲状腺平衡参数.
主要方法:
- 一项横截面研究包括1263名严重抑郁症患者,1619名双相情感障碍患者,1186名精神分裂症患者和162名健康对照人群.
- 无毒状态被定义为没有至少4个月的精神药物暴露.
- 关键结果包括甲状腺的分泌能力 (SPINA-GT),二氧激酶活性 (SPINA-GD),总和自由甲状腺素的比率,TSH指数和TFQI.
主要成果:
- 与健康对照人群相比,情绪障碍者表现出较低的SPINA-GD和总与自由甲状腺素比率.
- 双极性障碍与躁狂症的SPINA-GT比双极性抑郁症和严重抑郁症更高.
- 精神分裂症患者的TSH指数和TFQI都升高,与主要抑郁症和双相情感障碍患者不同.
结论:
- 情绪障碍呈现出独特的甲状腺静止概况,其特点是受损的二氧化酶活性和减少的甲状腺激素结合.
- 甲状腺平衡的中央设置点在严重抑郁症和双相情感障碍中保持不变.
- 躁狂发作可能与甲状腺分泌能力的增加有关.
相关概念视频
01:28Drug Therapy
44
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
44
01:20Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
01:26Psychosis: Goals of Pharmacotherapy
131
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
131
01:28Psychosis and Antipsychotic Drugs: Overview
259
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
259
01:24Mania and Antimanic Drugs: Overview
181
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
181
01:23Antidepressant Drugs: MAOIs and Other Agents
234
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
234