释放CAR T细胞潜力:因诺辛诱导的干性和增强的功效
1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
Cancer cell
|January 26, 2024
概括
氨酸促进瘤免疫抑制. 研究人员发现,增加腺脱氨酶 (ADA-OE) 或使用 inosine (INO) 增强了CAR T细胞功能和干性,提供了新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 氨酸 (Ado) 是瘤微环境中的免疫抑制的关键调解者.
- 了解腺的作用对于开发有效的癌症免疫疗法至关重要.
研究的目的:
- 研究瘤中腺介导免疫抑制的机制.
- 评估调节腺代谢对CAR T细胞功能和干细胞的影响.
主要方法:
- 在瘤模型中过度表达腺脱氨酶 (ADA-OE).
- 对CAR T细胞暴露在因诺辛 (INO) 的作用下.
- 评估CAR T细胞功能,干细胞特征和瘤免疫抑制.
主要成果:
- 过度表达腺脱氨酶 (ADA-OE) 导致腺转化为 inosine (INO).
- 无论是ADA-OE还是直接暴露于因诺辛,都提高了CAR T细胞的功能.
- 在CAR T细胞中,inosine暴露诱导了干性特征,改善了它们的抗瘤潜力.
结论:
- 调节腺代谢,特别是通过增加腺水平,可以克服腺驱动的免疫抑制.
- 通过因诺辛增强CAR T细胞干细胞和功能,为改善癌症免疫治疗结果提供了一个有希望的策略.
更多相关视频
12:55Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
21.4K
10:44A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
Published on: August 9, 2019
7.3K
相关概念视频
01:29Somatic to iPS Cell Reprogramming
2.2K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.2K
01:24Methods of Nuclear Reprogramming
1.8K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.8K
01:06Induced Pluripotent Stem Cells
4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.1K
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
01:27Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526