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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K

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相关实验视频

Updated: Jul 4, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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一个类似于瘤与免疫系统相互作用的混合模型.

Christian Tayou Fotso1, Simon Girel1, Fabienne Anjuère2

  • 1Université Côte d'Azur, Inria, CNRS, LJAD, Parc Valrose, F-06108, Nice, France.

Journal of theoretical biology
|January 26, 2024
PubMed
概括

这项研究提出了瘤与免疫相互作用的数学模型,揭示了氧气和营养物质的供应对瘤生长具有重要影响. 抗瘤免疫细胞控制生长,而前瘤细胞促进扩张.

关键词:
癌症的生长 癌症的生长 癌症的生长免疫反应的免疫反应.混合模型的混合模型.

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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

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相关实验视频

Last Updated: Jul 4, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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科学领域:

  • 数学生物学 数学生物学
  • 计算瘤学计算瘤学
  • 免疫学 免疫学 免疫学

背景情况:

  • 瘤微环境的复杂性会影响癌症的进展.
  • 了解瘤-免疫系统动态对于有效的癌症治疗至关重要.

研究的目的:

  • 开发一个模拟瘤与免疫相互作用的数学模型.
  • 研究营养/氧气供应和免疫细胞对瘤生长动态的影响.

主要方法:

  • 利用混合理论来制定数学方程.
  • 纳入瘤几何学,免疫细胞迁移 (扩散,化疗) 和资源限制.
  • 执行数值模拟来分析模型行为.

主要成果:

  • 模型根据参数重现了瘤消除,平衡或逃生阶段.
  • 氧气和营养的可用性显著塑造瘤生长模式.
  • 抗瘤免疫细胞促进平衡;前瘤细胞驱动瘤扩张.

结论:

  • 数学建模提供了对瘤免疫动态的洞察.
  • 资源的可用性和免疫细胞种群是瘤命运的关键决定因素.
  • 该模型可以通过针对这些因素来指导癌症治疗策略.