甜菜提取物@chitosan纳米复合物作为癌症治疗的有希望的方法
Gamal El-Ghannam1, Mahmoud Moawad2, Mahmoud T Abo-Elfadl3
1National Institute of Laser Enhanced Sciences (NILES), Department of Laser Applications in Metrology, Photochemistry, and Agriculture (LAMPA), Cairo University, 12613 Giza, Egypt.
International journal of biological macromolecules
|January 26, 2024
概括
甜菜 (BR) 和素纳米颗粒 (CS NP) 结合在一起,创造了一种用于癌症治疗的新型纳米复合材料 (NC). 这种BR@CSNC有效地消除了83%-89%的肺癌,乳腺癌和结肠癌细胞,提供了一个有前途的新疗法策略.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 癌症研究 癌症研究
背景情况:
- 甜菜 (BR) 具有强大的抗氧化和抗炎性质.
- 素纳米颗粒 (CS NP) 具有抗癌作用,包括抗血管生成和瘤抑制.
- 结合BR和CSNP提供了加强癌症治疗的协同方法.
研究的目的:
- 为了合成和表征一种新的甜菜-奇托桑纳米复合物 (BR@CS NC).
- 评估BR@CS NC对人类肺癌 (A549),乳腺癌 (T-47D) 和结直肠癌 (Caco-2) 细胞系的体外抗癌疗效.
- 研究由BR@CSNC诱导的细胞死亡机制.
主要方法:
- 使用SEM,UV-VIS,FTIR和泽塔潜力分析合成BR@CSNC和表征.
- 用BR@CS NC治疗A549,T-47D和Caco-2癌细胞系,其度为250μg/mL.
- 评估细胞活力,细胞死亡模式 (细胞亡,亡) 以及Caspase 3 (CasP3) 和P53.3的水平.
主要成果:
- SEM确认的CS NP大小在20-58nm之间. UV-VIS和FTIR验证了具有强结合的BR@CS NC形成.
- BR@CS NC显示显著的癌细胞根除:A549的89%,T-47D的88%,Caco-2的83%.
- BR@CS NC诱导了广泛的亡和亡细胞死亡,治疗细胞中的CasP3和P53水平升高.
结论:
- BR@CS NC是一种新型,稳定的纳米复合物,具有显著的体外抗癌活性.
- 该纳米复合材料有效地诱导多个人类癌症细胞系的亡和亡.
- 这项研究通过结合甜菜和奇托桑纳米颗粒的好处,为癌症治疗提供了一个有希望的,创新的策略.
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